Alcoholism & Alcoholic Liver Disease

Alcoholism remains a serious problem. Beyond the very serious consequences of driving (and in rare instances flying) while intoxicated, most of the 200,000 alcoholics who die annually in the U.S. die from complications of alcoholic liver disease.

About 15 - 20 % of individuals who drink more than 40 to 80 gms of ethanol a day, for over 10 years, will develop cirrhosis. Some, mostly women, will develop cirrhosis from drinking much less.

Alcoholism: Concept

  • The World Health Organization defines it as follows:  "Alcoholics are those excessive drinkers whose dependence upon alcohol has reached such a degree that it results in noticeable mental disturbance or in an interference with their bodily and mental health, their interpersonal relations, their smooth social and economic functioning, or those who show the signs of such developments." T

  • The American Medical Association defines alcoholism as: An illness characterized by significant impairment of physiological, psychological or social functioning that is directly associated with persistent and excessive alcohol use.

  • Others define "an alcoholic" as: Anybody whose drinking has seriously begun to interfere with one or more of the following aspects of his life: [1.] Family life; [2.] Social life; [3.] Legal life; [4.]  Financial life; [5.] Physical Health; [6.] Mental Health; [7.] Spiritual life, and; [8.] Occupational life.

The fine line between alcohol abuse and alcohol dependence (alcoholism) is blurred and often judgmental or circumstantial. Often it is much more prudent to classify a diagnosis as alcohol dependence and afford the individual the best chance at rehabilitation, as well as recovery and preservation of life, family and career.

Alcoholism & the various Forms of Liver Involvement:

  • Fatty Liver

The mildest form of liver involvement is a fatty liver. Patients with fatty liver are usually asymptomatic, although they may have tender hepatomegaly. 

Liver enzymes and bilirubin are normal or only mildly elevated. 

These patients have an excellent prognosis if they abstain from alcohol. The fatty changes are rapidly reversible once drinking is discontinued. 

Aviation personnel should be grounded and treated aggresively for alcohol dependance - The decision to return them to flying duties is usually dependent on the success of their achieving and maintaining sobriety. From an internal medicine standpoint, they are qualified to resume flying if they have normal hepatic function, as evidenced by normal liver enzymes, bilirubin, albumin, prothrombin time, and CBC; and  there is no history or evidence of portal hypertension.

  • Alcoholic Hepatitis

Alcoholic hepatitis is a much more serious disorder characterized by anorexia, nausea, vomiting, weight loss, abdominal pain, fever and jaundice. 

Portal hypertension may cause ascites, spleenomegaly and bleeding esophageal varicies. 

Liver enzymes are elevated five to 10 times normal, with SGOT being significantly more elevated than SGPT. 

Jaundice is present at times accompanied by hypoalbuminemia, prolonged prothrombin times and anemia. 

Some patients may progress to hepatic failure or hepatorenal syndrome. Although some patients recover fully, most either continue to have hepatitis or develop cirrhosis.

  • Cirrhosis

Cirrhosis represents the end stage of alcoholic liver disease where the liver has dense bands of connective tissue and areas of micronodular regeneration. 

Symptoms are caused by hepatic dysfunction and portal hypertension.