Nutritional Disorders:

Mineral Deficiency & Toxicity

Macrominerals: Six macrominerals are required by humans in amounts varying from 0.3 to 2.0 g/day: 

1. Four cations:

  • Sodium 

  • Potassium

  • Calcium

  • Magnesium

2. Two anions:

  • Phosphate

  • Chloride

Microminerals: Nine trace minerals - microminerals - are required by humans in small amounts (micrograms to milligrams per day): 

  • iron

  • iodine 

  • fluorine

  • zinc

  • Chromium

  • Selenium

  • Manganese

  • Molybdenum

  • Copper.  

Except for fluorine and chromium, each of these minerals is a component of an enzyme or endocrine system. All trace minerals are toxic at high levels, and some (arsenic, nickel, and chromium) have been implicated in carcinogenesis.

Except for deficiencies of iron, zinc and iodine, mineral deficiencies do not often develop spontaneously in adults on ordinary diets; however, infants are more vulnerable because of their rapid growth and variation in intake. 

The use of synthetic diets for the treatment of inborn errors of metabolism and the development of parenteral nutrition and renal dialysis, all of which present iatrogenic risks, demonstrate the nutritional importance of trace minerals. 

Toxicity can result from the excess intake of trace minerals - for example, in "health foods" touted as a source of protection against chronic diseases. Sometimes mineral deficiency or toxicity is caused by hereditary diseases.

Source: Merck