Introduction to Heat Disorders:

Heat Stroke ~ Heat Exhaustion ~ Heat Cramps

Heat disorders: Mild to grave reactions to high environmental temperature due to inadequate or inappropriate responses of heat-regulating mechanisms.

Exposure to high ambient temperature without efficient heat loss may lead to heat cramps, heatstroke, or heat exhaustion. Acute (eg, 3 to 4 h of strenuous effort) or prolonged (10 to 12 days) exposure to heat with excessive sweating uncompensated by fluid intake leads to dehydration, sodium and potassium depletion, and hypovolemia. Associated vomiting and diarrhea contribute to fluid loss. Evaporation, the most important source of heat loss, depends on relative humidity: The higher the humidity, the less efficient the heat loss. Therefore, high ambient humidity (which decreases the cooling effect of sweating) and prolonged strenuous exertion (which increases heat production by muscle) increase the risk of developing heat disorders. Age, obesity, chronic alcoholism, debility, and many drugs (eg, anticholinergics, antihistamines, phenothiazines, numerous psychoactive drugs, alcohol, cocaine) increase susceptibility to heat disorders, particularly heatstroke. Heatstroke and heat exhaustion both occur in hot, humid environments, but they are markedly different disorders.

Prophylaxis - Prevention

Using common sense is best. Strenuous exertion in a very hot environment or in an inadequately ventilated space should be avoided, and heavy insulating clothing should not be worn. If exertion in a hot environment is unavoidable, fluid and electrolytes (often lost imperceptibly in very hot, very dry air) should be replaced by frequently drinking fluids slightly salty to taste (ie, near isotonic), and evaporation, which helps keep the skin cool, should be facilitated by wearing open mesh clothing or using fans. Thirst is a poor indicator of dehydration. During strenuous exercise, fluids should be drunk every hour regardless of thirst. Salt tablets, which are less desirable than lightly salted beverages and foods, should not be taken unless large amounts of fluids are consumed. Depletion of potassium, magnesium, and calcium is hazardous only when heat exposure is prolonged.

Type of Heat Disorders:

A. Heatstroke - Sunstroke; Thermic Fever; Siriasis

Inadequacy or failure of heat loss mechanisms resulting in dangerous hyperpyrexia.

Symptoms and Signs

An abrupt onset is sometimes preceded by headache, vertigo, and fatigue. Sweating is usually decreased, and the skin is hot, flushed, and usually dry. The pulse rate increases rapidly and may reach 160 to 180 beats/min; respirations usually increase, but BP is seldom affected. Disorientation may briefly precede unconsciousness or convulsions. The temperature climbs rapidly to 40 to 41° C (104 to 106° F), causing a feeling of burning up. Circulatory collapse may precede death; after hours of extreme hyperpyrexia, survivors are likely to have permanent brain damage.

Diagnosis and Prognosis

Sudden development of hot, dry, flushed skin with a body temperature > 40° C (> 104° F), a rapid pulse, and confusion or unconsciousness in a person exposed to a hot environment are usually enough to distinguish heatstroke from food, chemical, or drug poisoning. An acute infection (eg, septicemia, meningitis) and toxic shock must be excluded. Drugs (see above) that may have precipitated the episode should be considered.

Heatstroke is a life-threatening emergency and, unless promptly and energetically treated, results in convulsions and death, permanent brain damage, or renal failure. A core temperature of 41° C (106° F) is a grave prognostic sign; a temperature even slightly higher is often fatal. Old age, debility, and alcoholism worsen the prognosis.

Treatment

Heroic measures should be instituted immediately. If far from a hospital, the patient should be removed from the heat, wrapped in wet bedding or clothing, and fanned vigorously to increase evaporative heat loss. Immersion in a lake or stream, or even cooling with snow or ice, while waiting for transportation is a good alternative. If the patient starts to shiver, the cooling process should be slowed, because shivering increases core temperature. Warning: The temperature should be taken every 10 min and not allowed to fall below 38.3° C (101° F) to avoid a continued fall resulting in hypothermia. In the hospital, the core temperature is monitored continuously to make sure it is stable. Stimulants and sedatives, including morphine, are avoided; diazepam or a barbiturate may be given IV if convulsions cannot be controlled otherwise. Frequent electrolyte determinations should guide IV therapy. After severe heatstroke, bed rest for a few days is desirable, and temperature may be labile for weeks.

B. Heat Exhaustion

Excessive fluid and electrolyte loss due to sweating, resulting in hypovolemia and electrolyte imbalance.

Symptoms and Signs

Excessive sweating without concomitant fluid replacement causes heat exhaustion with increasing fatigue, weakness, and anxiety. Circulatory collapse ensues, with a slow, thready pulse; low or imperceptible BP; cold, pale, clammy skin; and disordered mentation followed by a shocklike unconsciousness. Core temperature ranges from 38.3 to 40.6° C (101 to 105° F). Mild heat exhaustion, precipitated by prolonged standing in a hot environment (because blood pools in heat-dilated vessels in the legs), is manifested by a subnormal body temperature and simple syncope.

Diagnosis, Prognosis, and Treatment

Heat exhaustion causing circulatory collapse is more difficult to differentiate from insulin shock, poisoning, hemorrhage, or traumatic shock than is heatstroke. Usually, a history of heat exposure, lack of hydration, absence of another apparent cause, and response to treatment are sufficient for the diagnosis. Heat exhaustion is usually transient, and the prognosis is good unless circulatory failure is prolonged.

Normal blood volume must be restored, and adequate brain perfusion ensured. The patient should be placed flat or with the head down. Small amounts of cool, slightly salty fluids or sport electrolyte beverages should be given orally every few minutes. Isotonic saline IV, cardiac stimulants, and plasma volume expanders (albumin, dextran) are seldom needed; if used, they are given cautiously to avoid volume overload.

C. Heat Cramps

Exercise-induced cramps of striated muscle resulting from excessive fluid intake without sodium replacement.

Heat cramps occur after exercise at high ambient temperatures (> 38° C [> 100° F]) when fluids lost through excessive sweating are replaced only by water. The result is a relative loss of sodium and occasionally potassium and magnesium. Heat cramps are common in manual laborers (eg, engine room personnel, steel workers, miners), in mountaineers or skiers overdressed for the cold, in tennis players and other weekend athletes, and in persons not acclimatized to hot, dry climates in which excessive sweating is almost undetected because of rapid evaporation.

Symptoms and Signs

Onset is often abrupt, with muscles of the extremities affected first. Severe pain and carpopedal spasm may incapacitate the hands and feet. Often episodic, the cramping makes muscles feel like hard knots. When the cramps affect only abdominal muscles, the pain may simulate an acute abdomen. Vital signs are usually normal. The skin may be hot and dry or clammy and cool, depending on the humidity.

Prophylaxis and Treatment

Awareness of heat cramps is usually sufficient to prevent them. In most instances, heat cramps are prevented and rapidly relieved by drinking fluids or eating foods containing sodium chloride. Sodium chloride tablets are often used for prophylaxis but can cause stomach irritation, and overdose may lead to edema. Use of these tablets should be discouraged. If the patient cannot eat or drink, 0.9% sodium chloride IV may be necessary.

[Merck Manual]